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The once-weekly soup X was selected as the control because it was manufactured by a commercial cultivar of broccoli and was expected to be a part of a normal diet and not expected to play a significant role in cancer progression due to the low threshold of glucoraphanin concentration (28)

Recent reports confirm that miR-155 has significant impact on development of pain and pain hypersensitivity, where up-regulation of miR-155 is accompanied by enhanced activation of microglia and consequent production of inflammatory mediators (Kou et al., 2020)